How long PRF (platelet-rich-fibrin) last?

Platelet-rich fibrin (PRF) is a platelet-rich product that has gained popularity in recent years for its potential to promote tissue regeneration and wound healing. The duration of PRF varies depending on the specific clinical indication, the location of the treatment, and the individual patient’s healing process. PRF is a natural and slow-release matrix that provides a sustained release of growth factors and cytokines for up to seven days, promoting the regeneration of soft and hard tissues. It has been shown that PRF can enhance tissue regeneration by stimulating cell proliferation, angiogenesis, and extracellular matrix production. The slow-release property of PRF is due to its natural 3D matrix composed of fibrin, leukocytes, and platelets. In plastic surgery, PRF has been used to enhance wound healing and reduce scarring. The slow-release property of PRF provides a sustained release of growth factors that can promote angiogenesis, cell proliferation, and collagen synthesis. In a study, it was shown that PRF can reduce postoperative edema and pain and enhance the aesthetic outcome of facial rejuvenation surgery. In orthopedics, PRF has been used to promote tissue healing and regeneration for a range of conditions, including tendonitis, osteoarthritis, and rotator cuff tears. The duration of PRF in orthopedics may vary depending on the specific condition and the location of the treatment. In a study, it was shown that PRF can enhance the healing of rotator cuff tears for up to six months. In summary, the duration of PRF varies depending on the specific clinical indication and the individual patient’s healing process. PRF is a natural and slow-release matrix that provides a sustained release of growth factors and cytokines for up to seven days. The slow-release property of PRF promotes tissue regeneration and wound healing and has been used for a range of conditions in dental and oral surgery, plastic surgery, and orthopedics.