PDO (Polydioxanone) is a versatile and innovative synthetic monofilament suture that is becoming increasingly popular in the field of aesthetic medicine. This material is characterized by its flexibility, low tissue reactivity, and durability compared to other suture materials such as polypropylene. PDO has a long lifespan in the body, gradually being hydrolyzed over approximately 180 days, making it a safe choice for cosmetic treatments. With the ability to be altered using laser technology, PDO threads can be molded into various configurations, including unidirectional and bidirectional barbs, for greater tensile strength and improved lift. This versatility has made PDO a popular choice for soft tissue approximation and ligation in a range of surgical procedures, including plastic surgery, cardiac surgery, and orthopedics. With its long-standing reputation as a safe and nonallergic material, PDO is now being used to enhance facial appearance and rejuvenate skin through thread lifting and other aesthetic treatments.